Projects

Research in the lab studies regulation and physiological functions of arterial smooth muscle cell plasma membrane and intracellular ion channels and local and global intracellular Ca²⁺ signals.  We use a multi-faceted approach that incorporates many techniques, including patch-clamp and conventional electrophysiology, high speed confocal Ca²⁺ imaging,  ratiometric Ca²⁺ imaging, and pressurized arterial diameter myography.  We also use a wide range of molecular biology techniques, including genetic knockout models, cloning, siRNA/shRNA, adenoviral expression, RT-PCR, Western blotting, and recombinant protein expression.  

Some of our recent projects include:

Inositol 1,4,5 trisphosphate regulation of arterial TRP channels, calcium signals, and diameter.

Voltage-dependent Ca²⁺ channels and auxiliary subunits.

Mitochondrial modulation of arterial smooth muscle cell calcium signaling, ion channel activity, and contractility.

Vasoregulation by carbon monoxide (CO), a physiological gasotransmitter.