Education
1989 Bachelor of Engineering, Instrumentation & Control; Bharathiar University, India
1993 Master of Science, Biomedical Engineering; Medical College of Virginia, VA
1999 Doctor of Philosophy, Bioengineering; the Pennsylvania State University, PA
Research Interest
Research in the laboratory aims to understand the cellular signaling mechanisms underlying the development of spatially extensive inflammation that is characteristic of acute lung injury and acute respiratory distress syndrome. The focus of the present studies is on intercellular communication and gap junctions. The studies will determine the role of the gap junction protein, connexin in mediating the spatial spread of inflammation.
Studies are done using both
in vivo and
ex vivo rodent organ preparations visualized using wide-angle and confocal microscopy.
Selected Publications
Parthasarathi K, and H.H. Lipowsky. Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability.
Am J Physiol. 277(6 Pt 2): H2145-57, 1999.
PubMedKuebler WM, K. Parthasarathi, P.M. Wang, J. Bhattacharya. A novel signaling mechanism between gas and blood compartments of the lung.
J Clin Invest. 105(7): 905-13, 2000.
PubMed
Parthasarathi K, H. Ichimura, S. Quadri, A. Issekutz, and J. Bhattacharya. Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries.
J Immunol. 169(12): 7078-86, 2002.
PubMedIchimura H, K. Parthasarathi, A. Issekutz, and J. Bhattacharya. Mechano-oxidative coupling by mitochondria induced P-selectin expression in pressure-stressed capillaries.
J Clin Invest. 111: 691-699, 2003.
PubMedQuadri S, K., M. Bhattacharjee, K. Parthasarathi, T. Tanita and J. Bhattacharya. Endothelial barrier strengthening by activation of focal adhesion kinase.
J Biol Chem. 278(15): 13342-13349, 2003.
Ichimura H*, K. Parthasarathi*, A. Issekutz, J. Bhattacharya. Pressure-induced leukocyte margination in lung postcapillary venules.
Am J Physiol Lung Cell Mol Physiol. 289(3): L407-12, 2005. (*both authors contributed equally)
PubMedPadilla J, E. Daley, A. Chow, K. Robinson, K. Parthasarathi, A. McKenzie, T. Tschernig, V. Kurup, D. Donaldson, G. Grunig. IL-13 regulates the immune response to inhaled antigens.
J Immunol. 174(12): 8097-105, 2005.
Ichimura H*, K. Parthasarathi*, J. Lindert, J. Bhattacharya. Lung surfactant secretion by inter-alveolar Ca2+ signaling.
Am J Physiol - Lung Cell & Molecular Physiology. 291: L596-601, 2006. (*both authors contributed equally)
PubMedK. Parthasarathi, H. Ichimura, E. Monma, J. Lindert, S. Quadri, A. Issekutz, and J. Bhattacharya. Connexin 43 mediates spread of Ca2+ dependent proinflammatory responses in lung capillaries.
J Clin Invest. 116: 2193-200, 2006.
PubMed Lindert J, Perlman CE, Parthasarathi K, Bhattacharya J. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy.
Am J Respir Cell Mol Biol. 36(6):688-96, 2006.
PubMedBertuglia S, Ichimura H, Fossati G, Parthasarathi K, Leoni F, Modena D, Cremonesi P, Bhattacharya J, Mascagni P. ITF1697, a Stable Lys-Pro-Containing Peptide, Inhibits Weibel-Palade Body Exocytosis Induced by Ischemia/Reperfusion and Pressure Elevation.
Mol Med. 13(11-12):615-24, 2007.
Kiefmann R, Islam M, Lindert J, Parthasarathi K, and Bhattacharya J. Paracrine purinergic signaling determines lung endothelial nitric oxide production.
Am J Physiol - Lung Cell & Molecular Physiology.
In Press